成年患者心脏自主功能和心房节律失常在Fontan息后具有单心室生理学的成人患者
Marieke Nederend1,2, Elizaveta Polyakova3, Philippine Kiès1,2
1CAHAL, Center for Congenital Heart Disease Amsterdam Leiden, Leiden University Medical Center, Leiden, the Netherlands.
CJC pediatric and congenital heart disease
|March 2, 2026
概括
成年Fontan患有心房律乱的患者表现出自主功能受损和运动能力降低. 解决自主功能障碍可能会降低这种人群中的心律失常风险.
科学领域:
- 心脏病学 心脏病学
- 自主神经系统的自主神经系统
- 电力生理学 电力生理学
背景情况:
- 心律不整是常见的Fontan循环患者.
- 自主功能障碍与心律失常有关.
- 自主功能,心脏结构和成年Fontan患者的结果之间的联系尚不清楚.
研究的目的:
- 评估成人Fontan患者的心脏自主功能,使用心率变化和运动测试.
- 在这个队列中确定与心房律乱相关的自主因素.
主要方法:
- 连续成年Fontan患者的单中心,横截面研究.
- 通过24小时心电图和运动测试评估心脏自主功能.
- 分析了与心房律乱相关的因素.
主要成果:
- 26%的患者患有心房律不整,与运动期间心率储备和慢性指数较低有关.
- 在患有心房失常症的患者中观察到心率可变性参数 (SDNN,SDNN-5min) 的降低,独立于β-阻断剂的使用.
- 心室心律不整不太常见 (7%).
结论:
- 成年Fontan患者的心房节律失常与自主调节和适应能力受损相关.
- 降低心率储备和慢性指数,以及心率变异性降低,表明自主功能障碍.
- 针对自主功能障碍可能是减轻Fontan幸存者的心律失常风险的关键.
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