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Updated: Mar 3, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

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关于涉及印甲醇的有机催化不对称循环添加/取消反应的最新进展

Arun Patel1, Harshit1, Eldhose Iype2

  • 1Department of Chemistry, Birla Institute of Technology and Science, Pilani, Pilani Campus Vidya Vihar Pilani Rajasthan 333031 India indresh.chemistry@gmail.com indresh.kumar@pilani.bits-pilani.ac.in.

RSC advances
|March 2, 2026
PubMed
概括

对药物发现来说,合成丰富的醇框架至关重要. 这项研究突出了N-英多甲醇作为不对称催化中的关键前体,特别是在使用奇拉酸的enantioselective循环添加剂中.

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Robinson annulation is a base-catalyzed reaction for the synthesis of 2-cyclohexenone derivatives from 1,3-dicarbonyl donors (such as cyclic diketones, β-ketoesters, or β-diketones) and α,β-unsaturated carbonyl acceptors. Named after Sir Robert Robinson, who discovered it, this reaction yields a six-membered ring with three new C–C bonds (two σ bonds and one π bond).
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