甲状腺功能低下症的肠道微生物群变化:一项试点研究显示,特定细菌基因的丰富性增加
Zahra Hoseini Tavassol1, Farima Farsi1, Fateme Ettehad-Marvasti1
1Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran, tums.ac.ir.
Journal of nutrition and metabolism
|March 2, 2026
概括
甲状腺功能低下的患者表现出改变的肠道细菌,包括更高水平的Bacteroides和Prevotella. 这表明肠道微生物组可能会影响甲状腺功能,可能会开辟新的治疗途径.
科学领域:
- 微生物学 微生物学
- 内分泌学 在内分泌学.
- 胃肠病学 胃肠病学
背景情况:
- 甲状腺功能低下症 (HT) 是一种常见的内分泌疾病,与甲状腺激素生产不足有关.
- 新出现的证据表明,肠道微生物群与甲状腺调节之间存在联系.
- 肠道细菌的变化可能在HT的发展和进展中起作用.
研究的目的:
- 为了比较患有甲状腺功能低下症的个体与健康对照者的肠道微生物群组成.
- 调查肠道失调和甲状腺功能障碍之间的潜在联系.
- 探索针对肠道微生物组的HT新型诊断和治疗策略.
主要方法:
- 试点研究涉及15名HT患者和15名匹配的健康对照 (2019-2023年).
- 用定量实时PCR针对16S rRNA基因分析了便样本的微生物组成.
- 使用曼-惠特尼U测试进行的统计分析.
主要成果:
- 群体之间基线人口统计或人体统计没有显著差异.
- 在HT患者中观察到显著增加的Bacteroides,Bifidobacterium,Escherichia,Fecalibacterium和Prevotella水平 (p < 0.001-0.030).
- 在Akkermansia,Lactobacillus或Bacteroides/Prevotella比率方面没有显著差异.
结论:
- 初步发现表明肠道微生物群在HT病理生理学中的潜在作用.
- 肠道微生物组的变化表明对甲状腺调节有重大影响.
- 需要对更大的队列进行进一步的研究,以阐明途径,并开发针对HT的微生物向疗法.
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