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Updated: Mar 3, 2026

A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9
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A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9

Published on: August 28, 2018

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细胞表面LDL受体的PCSK9介导的降解会损害人类CD8+ T细胞的效应器功能

Angela Markovska1,2, Lara F Lommers1, Alejandra Bodelón1

  • 1Center for Translational Immunology, University Medical Centre Utrecht, Utrecht, the Netherlands.

iScience
|March 2, 2026
PubMed
概括

蛋白转化酶亚素/素9型 (PCSK9) 通过降低LDL受体,损害CD8+T细胞的抗瘤免疫力. 抑制PCSK9可能会提高癌症免疫治疗的有效性.

关键词:
细胞生物学 细胞生物学免疫学 免疫学 免疫学

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