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循环的incRNA及其与缺血性中风严重程度和预后的关联:系统性审查和元分析

Mehran Jaberinezhad¹, Parnia Pouya², Anahita Najafi³

¹Clinical Research Development Unit of Tabriz Valiasr Hospital, Tabriz University of Medical Sciences Tabriz East Azerbaijan Province Iran.

Health science reports

|March 2, 2026

概括

长非编码RNAs (lncRNAs) 对中风严重程度和预后具有中等的预测价值. 进一步的研究是必要的,以确认它们在临床中风护理中的作用.

科学领域:

生物标志物生物标志物
神经学神经学
基因组学就是基因组学.

背景情况:

卒中是全球致病率的主要原因,需要改善患者护理的预后.
长非编码RNA (lncRNAs) 正在成为各种疾病的潜在生物标志物.
对中风预后的 lncRNAs 的评估可以提高患者的治疗和治疗结果.

研究的目的:

系统地评估循环长非编码RNAs (lncRNAs) 作为预测中风严重程度和预后的生物标志物的实用性.
综合现有研究中关于 lncRNA 水平与中风结果之间的相关性证据.

主要方法:

在主要数据库 (Medline,EMBASE,Web of Science,Scopus) 进行了系统的文献搜索,直到2024年4月.
包括集中在循环lncRNA水平和中风严重程度/预后的英语同行评审论文中的研究.
使用STROBE,QUIPS和NOS检查清单来评估研究质量和报告的完整性.

主要成果:

包括30项涉及3719名患者的研究,重点关注缺血性中风和TIA (没有血液性中风的数据).
聚合的相关系数表明lncRNAs和中风严重程度尺度之间存在中等关联 (NIHSS:0.52,mRS:0.49).
对于预测死亡率,LncRNAs的合并几率比为1.55,大多数研究显示偏差低,报告完整度高.

结论:

循环的长非编码RNAs (lncRNAs) 在预测中风严重程度和预后方面表现出适度到中度的准确性.
这些发现表明 lncRNAs 在中风预后方面具有潜在的实用性.
建议进行进一步的研究,以验证和巩固 lncRNAs 在临床中风管理中的作用.

关键词:

这就是IncRNARNA.没有编码的RNA.预后预后预后一次性中风中风中风中风中风

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