生命早期的抗生素暴露和1型糖尿病风险:系统审查和元分析
Callum De Pasquale1,2, Leonard C Harrison1,2
1Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Frontiers in endocrinology
|March 2, 2026
概括
孕妇在受孕前使用抗生素,特别是类,硫胺类或四环素,与后代患1型糖尿病 (T1D) 的风险增加有关. 其他暴露时期没有显著的关联.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物组研究 微生物组研究
- 公共卫生 公共卫生
背景情况:
- 暴露于抗生素可以改变肠道微生物群和婴儿免疫发育.
- 早期使用抗生素与1型糖尿病 (T1D) 风险有着不一致的联系.
- 了解这种关联对于公共卫生和预防策略至关重要.
研究的目的:
- 系统地审查和元分析早期抗生素暴露与T1D发展之间的关联.
- 调查特定的抗生素类别和暴露时间与T1D风险相关的情况.
- 为了确定T1D的潜在可修改的风险因素.
主要方法:
- 观察性研究的系统审查和元分析.
- 在Medline,Embase,Web of Science和Scopus数据库中进行了搜索.
- 包括20项研究,涉及10,960例T1D病例,分析了从怀孕前到产后24个月的数据.
主要成果:
- 孕前母亲对类,硫胺/三甲或四环素抗生素的暴露与T1D的几率增加有关 (ORs从1.23到1.34不等).
- 对于产前,新生儿或产后的抗生素暴露,没有发现显著的关联.
- 聚合的几率比率 (ORs) 和危险比率 (HRs) 用95%的置信区间 (CI) 来计算.
结论:
- 对特定类型的抗生素暴露可能是对后代T1D的可修改的孕产妇风险因素.
- 研究结果表明,这对抗生素处方指南有潜在的影响.
- 需要进一步的研究来验证这些关联,并探索暴露的精确时间.
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