案例报告: 发育类骨形变形和过渡性骨质硬化作为原发性副甲状腺炎症的罕见表现
Peijun Deng1, Qin Wang2, Miaoxian Huang1
1Department of Orthopaedic Surgery, Guangzhou First People's Hospital, the Second Affiliated Hospital, South China University of Technology, Guangzhou, China.
Frontiers in endocrinology
|March 2, 2026
概括
原发性偏甲状腺症 (PHPT) 可以模仿青少年的骨变形,如coxa vara和genu valgum. 这个病例显示了成功的手术纠正和甲状腺切除术后的新的骨愈合反应.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 整形外科手术 整形外科手术
- 骨生物学 骨生物学
背景情况:
- 原发性偏甲状腺症 (PHPT) 典型的原因是骨质疏松症或棕色瘤.
- 在资源有限的环境中记录了骨变形,但没有报告有 genu valgum 的 coxa vara.
- 在青少年中,PHPT可以异常呈现,模仿发育性骨问题.
研究的目的:
- 报告一个罕见的PHPT病例,该病例在青少年中呈现为严重的双边和真.
- 描述复杂的下肢形和并发PHPT的成功管理.
- 要突出在PHPT中暂时的术后骨质硬化症的新观察.
主要方法:
- 一名14岁的女性患有渐进性骨和真骨,接受了分阶段的骨切除术.
- 通过生物化学测试和SPECT扫描确认了PHPT的诊断,确定了副甲状腺腺瘤.
- 治疗涉及甲状腺切除术 (PTX),随后进行分阶段的骨科手术,并进行密集的外科外代谢管理.
主要成果:
- 这位患者出现了严重的双边形和真形,需要进行手术纠正.
- 生物化学分析显示严重的高血症和升高的PTH,导致副甲状腺腺瘤的PTX.
- 手术后的过渡性骨质硬化症被观察到,并在一年内通过补充和维生素D而消失.
- 阶段性骨切除术成功完成,实现了形纠正和功能恢复.
结论:
- 在青少年患有无法解释的骨变形,需要进行生化查时,应该考虑PHPT.
- 在PHPT治疗后的过渡性术后骨质硬化可能代表骨的修复性反应.
- 在PHPT患者在完全代谢正常化之前,可以进行分阶段的骨科纠正,并且需要仔细的术后护理.
- 这个案例扩大了儿科PHPT已知的表型谱.
关键词:
骨质切除术 (osteotomy) 是一种骨质切除术.副甲状腺切除术 (parathyroidectomy) 是一种切除甲状腺的方法.原发性副甲状腺功能障碍症.骨的变形 骨的变形过渡性骨质硬化症 过渡性骨质硬化更多相关视频
07:12Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
Published on: August 17, 2022
5.0K
07:13Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
Published on: March 14, 2017
15.4K
相关概念视频
01:29Bone Disorders
5.7K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.7K
00:59The Parathyroid Glands
5.5K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
5.5K
01:02What is the Skeletal System?
58.1K
Overview
58.1K
01:17Hormones and Bone Tissue
4.0K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
4.0K
01:40Bone Remodeling
40.7K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.7K
01:21Skeleton and Calcium Homeostasis
6.3K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
6.3K