环境内分泌干扰物和子宫内膜癌:流行病学研究的系统审查
Dalila Incognito1,2, Claudia Gelsomino1, Antonio Picone3
1Medical Oncology Unit, Department of Human Pathology "G. Barresi", School of Specialization in Medical Oncology, University of Messina, Messina, Italy.
Frontiers in endocrinology
|March 2, 2026
概括
内分泌干扰化学物质 (EDC) 可能会增加子宫内膜癌 (EC) 的风险. 暴露显示出积极的关联,特别是在瘦身的绝经后妇女中,而其他EDC的证据仍然有限.
科学领域:
- 环境健康 环境健康
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
背景情况:
- 子宫内膜癌 (EC) 是一个日益严重的全球健康问题.
- 内分泌干扰化学物质 (EDC) 通过雌激素受体 (ER) 途径被怀疑是EC的贡献者.
研究的目的:
- 系统地审查流行病学证据,将EDC暴露与子宫内膜癌风险联系起来.
- 确定与欧洲共同体发展相关的特定EDC.
主要方法:
- 在主要数据库 (MEDLINE,EMBASE,Scopus,Cochrane,ClinicalTrials.gov) 进行全面的文献搜索,截至2025年4月.
- 包括观察性和干预性研究,量化EDC暴露和EC发病率数据.
- 分析了八项符合条件的研究 (2609个EC病例,1577个对照).
主要成果:
- 暴露最常与EC有关,五项研究中的四项显示出显著的积极关联,特别是在瘦身的绝经后妇女中.
- 对双A (BPA) 和其代谢物的证据是不一致的;只有单-n-丁甲酸盐 (MnBP) 显示出正相关性.
- 有限的证据表明,非和八之间存在积极的关联;和异黄之间没有关联.
结论:
- 流行病学数据表明,暴露与EC风险增加之间存在潜在联系.
- 对其他EDC的证据有限且不确,需要进一步研究.
- 研究设计和暴露评估的异质性阻碍了最终的结论;需要精心设计的纵向研究.
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