作为超重和肥胖人口中食后高甘油三血症的预测生物标志物
Xiaoyu Wang1,2,3, Yale Tang1,2, Shaojing Zeng2
1Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, China.
Frontiers in endocrinology
|March 2, 2026
概括
低石样蛋白 (Metrnl) 与超重和肥胖个体的食后高甘油三血症 (PHTG) 有关. 将Metrnl与甘油三酸结合起来可以改善PHTG预测,为早期肥胖干预提供了洞察力.
科学领域:
- 代谢健康 代谢健康
- 肥胖问题研究研究
- 心血管疾病风险因素 心血管疾病风险因素
背景情况:
- 餐后高甘油三血症 (PHTG) 是心血管疾病的重要危险因素.
- 像石类蛋白质 (Metrnl) 一样,阿迪波金在超重和肥胖个体中PHTG中的作用尚不清楚.
- 早期识别PHTG风险对于有效的肥胖干预至关重要.
研究的目的:
- 为了研究血清Metrnl水平和PHTG在正常的禁食脂质样本的成年人之间的关联.
- 探索Metrnl作为早期脂质异常的生物标志物的潜力.
- 评估PHTG的Metrnl和禁食甘油三糖的联合诊断价值.
主要方法:
- 招募了105名正常禁食脂质的成年人,并将其分类为对照,超重或肥胖.
- 标准化口服脂肪耐受性测试 (OFTT) 用于评估食后脂质反应.
- 血清测量,脂质和禁食胰岛素被测量,动态脂质配置文件在食后进行分析.
主要成果:
- 血清Metrnl与PHTG,禁食甘油三和禁食胰岛素有负相关性.
- 禁食的甘油三被确定为PHTG的危险因素.
- Metrnl和禁食甘油三糖的组合模型在预测PHTG方面表现出高准确性 (AUC=0.908).
结论:
- 超重和肥胖的个体具有正常的禁食脂质面临PHTG的高风险.
- 低血清Metrnl与早期脂质异常和胰岛素抵抗有关.
- 将Metrnl测量与甘油三水平相结合,可以提高PHTG的诊断准确度.
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