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定量fs-激光晶体透镜软化手术,以基于光学连贯弹性图的长视治疗为基础

Zhuoyu Zhang^1,2, Haijun Lv^1,2, Hao Zhang^1,2

¹Britton Chance Center for Biomedical Photonics, MOE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China.

Biomedical optics express

|March 2, 2026

概括

五秒激光延伸切除术 (fs-lento) 通过在镜头中创建滑动平面来纠正近视. 这项研究引入了一种使用光连贯弹性学 (OCE) 来测量fs-lento手术后透镜组织的机械变化的定量方法.

科学领域:

眼科医生眼科眼科
生物医学工程生物医学工程
激光手术激光手术是一种激光手术.

背景情况:

长视,其特点是透镜硬化和失去了住宿,影响全球数百万人.
五秒激光延伸切除术 (fs-lento) 是一种新兴的技术,通过创建内滑动平面来恢复透镜弹性.
fs-lento的临床转化受到限制,因为在量化手术对组织力学的影响方面存在挑战.

研究的目的:

开发和验证一种定量方法,用于评估晶体透镜在fs-lento后的生物力学变化.
建立fs-lento手术参数和镜片组织机械性质的修改之间的关系.

主要方法:

开发一个秒激光眼科研究装置 (FLORA) 系统.
从SD-OCT修改的PZT接触光学连贯弹性图 (OCE) 系统的实施.
使用幻影实验验证OCE系统的验证,并将其应用于ex vivo猪眼镜.

主要成果:

使用特定参数的fs-lento程序 (16个花纹平面,4.1μJ脉冲能量,<50μm气泡),降低了前镜片的刚度.
测量的刚度从36.88 ± 1.93 kPa下降到31.39 ± 2.11 kPa.
证明了火速缓慢模式和生物机械变化之间的定量相关性.

结论:

开发的OCE系统提供了一种定量方法来评估fs-lento对镜片生物力学的影响.
这种定量方法可以帮助克服fs-lento质量控制和结果一致性的挑战.
这些发现支持fs-lento在长视障碍纠正方面的潜力,因为它可以精确控制透镜组织的修饰.

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