在自然方式和通过ART怀孕的后代之间,甲状腺激素配置没有差异
Yiyuan Zhang1,2,3,4,5,6,7,8, Yifei Sun1,2,3,4,5,6,7,8, Ting Lan1,2,3,4,5,6,7,8
1Center for Reproductive Medicine, The Second Qilu Hospital of Shandong University, Jinan, Shandong, 250012, China.
Human reproduction open
|March 2, 2026
概括
通过辅助生殖技术 (ART) 怀孕的儿童显示甲状腺功能与自然怀孕 (NC) 儿童相似. 新鲜和冷的胚胎移植方法似乎对儿童的长期甲状腺健康是安全的.
科学领域:
- 内分泌学 在内分泌学.
- 生殖医学 生殖医学
- 儿科 儿科 儿科
背景情况:
- 有限的研究存在于甲状腺功能在ART怀孕的儿童,与相互矛盾的发现.
- 现有的研究还没有在ART和自然受孕 (NC) 儿童之间一致比较甲状腺功能.
研究的目的:
- 调查甲状腺功能是否在通过辅助生殖技术 (ART) 怀孕的儿童和自然怀孕 (NC) 儿童之间有所不同.
- 为了在这些组之间比较甲状腺刺激激素 (TSH),自由三甲状腺素 (FT3),自由甲状腺素 (FT4) 和抗体水平 (A-TG,A-TPO).
主要方法:
- 中国的一项前性队列研究,涉及9450名儿童 (1,5-10岁).
- 包括3940个新鲜胚胎移植 (ET),4730个冷胚胎移植 (FET) 和780个NC儿童.
- 通用估计方程 (GEE) 分析了甲状腺激素和抗体水平.
主要成果:
- 在ART和NC组之间没有发现FT4水平或异常TSH,FT3,FT4,A-TG或A-TPO异常几率的显著差异.
- 与NC组相比,ET组在婴儿时期观察到暂时更高的TSH水平,但在年长的儿童中,这种情况正常化.
- 在所有年龄小组中没有观察到FT4水平的显著差异.
结论:
- 通过ART怀孕的儿童表现出与NC儿童相比的甲状腺功能概况.
- 包括新鲜和冷胚胎移植在内的ART程序在儿童的长期甲状腺功能方面似乎是安全的.
- 局限性包括缺乏尿数据和潜在的选择偏差,由于失去后续和性别不平衡.
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