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LILRB1调节中性粒细胞迁移,NETosis和炎症在耐药性Pseudomonas aeruginosa-相关的支气管切开症

Shaochu Zheng¹, Shihao Yang¹, Yuting Huang¹

¹Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People's Republic of China.

Infection and drug resistance

|March 2, 2026

概括

白血球免疫球蛋白样受体B1 (LILRB1) 在耐药性Pseudomonas aeruginosa支气管切开症患者中较低,抑制中性粒细胞活性. 在这些患者中,LILRB1可能是减少呼吸道炎症的治疗点.

科学领域:

免疫学免疫学免疫学
肺部病理学肺部病理学
微生物学微生物学

背景情况:

患有耐药性*Pseudomonas aeruginosa* (*P. aeruginosa*) 支气管炎症的患者经历了持续的中性友气道炎症.
在这种情况下,白细胞免疫球蛋白样受体B1 (LILRB1) 在调节中性粒细胞功能的作用尚未完全理解.
这项研究研究了LILRB1在耐药P. aeruginosa*相关支气管病的功能.

研究的目的:

描述LILRB1在耐药性P. aeruginosa*相关支气管病变中的功能.
调查LILRB1表达与疾病严重程度之间的关联.
评估LILRB1对中性粒细胞功能和炎症的调节作用.

主要方法:

患者样本中的量化LILRB1mRNA表达和可溶性HLA-G (sHLA-G) 水平.
刺激的中性粒细胞与耐药的P. aeruginosa和评估的NETosis.
研究了重组ILRB1蛋白对中性粒细胞迁移和细胞因子释放在共同培养模型中的影响.

主要成果:

与对照组相比,LILRB1表达在患者中明显较低,与疾病严重程度和中性粒细胞计数相反相关.
支气管洗液中sHLA-G水平升高与LILRB1表达相反相关.
重组LILRB1蛋白减弱了P. aeruginosa*诱导的中性粒细胞迁移,抑制了NETosis,并减少了促炎性细胞因子的释放.

结论:

LILRB1是药物耐药P. aeruginosa*相关支气管炎症中中性恋炎症的重要调节者.
LILRB1抑制中性粒细胞迁移,NETosis,以及促炎性细胞因子的释放.
在这种患者群体中,LILRB1代表了缓解炎症的潜在治疗标.

关键词:

在 HLA-G 的情况下.这就是LILRB1的意义.伪omonas空气菌伪omonas空气菌支气管切除症是一种支气管切除症.耐药性耐药性耐药性耐药性耐药性中性恋性炎症是一种中性恋炎症.

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