在制造含的聚合物化水凝时pH的影响
Alexandros Magiakos1, Spyridon Efstathiou1, Evelina Liarou1
1Department of Chemistry, University of Warwick, Coventry CV4 7AL, U.K.
Macromolecules
|March 2, 2026
概括
这项研究开发了响应pH的金基水凝,用于药物输送. 这些新型水凝具有可调节的机械性能和强大的抗菌活性,为现有的和疗法提供了有前途的替代方案.
科学领域:
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
- 化学 化学 化学
背景情况:
- (Pt) 和 (As) 药物面临的挑战是耐药性和毒性.
- 响应刺激的水凝为生物医学应用提供了可适应的平台.
- 开发新的含有Pt和As的药物输送系统至关重要.
研究的目的:
- 研究-水凝对pH反应的机械和抗菌性质.
- 探索pH对水凝完整性,动态和相互作用的影响.
- 评估这些水凝在感染治疗和向药物输送方面的潜力.
主要方法:
- 合成与PtII交联的聚N,N-二甲基烯胺-co-4-N-烯胺) - 利酸) (P(As)) 水凝.
- 使用光谱技术 (UV-vis,FT-IR,NMR) 和风湿学分析进行表征.
- 评估自我愈合,胀,形态变化 (SEM-EDX),以及对细菌菌株的抗菌活性.
主要成果:
- 在不同的pH值下,酸的质子化会影响Pt (II) -O-As (V) 相互作用和水凝的特性.
- 增加的pH值会增强机械刚性,这是由于加强了金属-连接体相互作用.
- 水凝表现出自我愈合能力和pH依赖的弹性,在中性环境中具有更好的稳定性.
- SEM-EDX证实了As和Pt的存在,具有pH调节的形态.
- 针对格拉姆阳性和格拉姆阴性细菌的抗微生物活性与单个成分相比可比或改善.
结论:
- -基水凝表现出可调节的pH响应的机械性能和自我愈合能力.
- 水凝表现出显著的抗微生物活性,表明感染治疗的潜力.
- 这些材料代表了先进药物输送系统的有希望的候选者,克服了当前Pt和As疗法的局限性.
相关概念视频
03:27Mixtures of Acids
The pH of a solution containing an acid can be determined using its acid dissociation constant and its initial concentration. If a solution contains two different acids, then its pH can be determined using one of several methods depending upon the relative strength of the acids and their dissociation constants.
A Mixture of a Strong Acid and a Weak Acid
In a mixture of a strong acid and a weak acid, the strong acid dissociates completely and becomes a source of almost all the hydronium ions...
A Mixture of a Strong Acid and a Weak Acid
In a mixture of a strong acid and a weak acid, the strong acid dissociates completely and becomes a source of almost all the hydronium ions...
04:01Factors Affecting Solubility
Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Chȃtelier’s principle. Consider the dissolution of silver iodide:
01:24pH
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01:19Quality of Water
In concrete preparation, the quality of water is paramount as it affects the strength and durability of the concrete. Potable water is usually preferred; however, it must not have excessive sodium or potassium to prevent compromising the concrete's integrity. Water quality is typically evaluated based on impurities such as dissolved solids, chlorides, and sulfates, and its pH value is ideally between 6 and 8. Even slightly acidic natural water may be acceptable unless it contains harmful...
01:21Acid Attack on Concrete
When acids come into contact with concrete, they initiate a chemical reaction that dissolves the hydrated cement paste. This process leads to softening and structural weakening of the concrete. This issue is commonly observed in environments such as chimneys, sewers, and industrial settings. The severity of the damage increases as the pH of the water interacting with the concrete drops below 6.5. In particular, a pH under 4.5 can cause significant concrete damage.
The rate at which hydrogen...
The rate at which hydrogen...
01:19Mixtures of Acids
The pH of a solution containing an acid can be determined using its acid dissociation constant and initial concentration. If a solution contains two different acids, then its pH can be determined using one of several methods depending on the relative strength of the acids and their dissociation constants.
In a strong and weak acid mixture, the strong acid dissociates completely and becomes a source of almost all the hydronium ions present in the solution. In contrast, the weak acid shows...
In a strong and weak acid mixture, the strong acid dissociates completely and becomes a source of almost all the hydronium ions present in the solution. In contrast, the weak acid shows...