毒素菌症:男性的精子参数和水平
Mohammad Matini1, Seyed Ali Hosseini1, Maryam Bahmanzadeh2,3
1Department of Medical Parasitology and Mycology, School of Medicine, Hamadan University of Medical Sciences, P.O. Box: 65157838736, Hamadan, Iran.
概括
毒素菌感染在男性中很常见,近一半的人表现出IgG抗体. 这种寄生虫感染可能会通过影响精子健康和功能而导致男性不孕,尽管它可能会导致男性不孕.
科学领域:
- 生殖免疫学 生殖免疫学
- 传染性疾病 传染性疾病
- 人类繁殖人类的繁殖.
背景情况:
- 毒素菌是一种广泛传播的寄生虫,影响了全球三分之一以上的人口.
- 虽然研究了其对女性生殖的影响,但对其对男性生殖健康,精子因素和丸激素的影响知之甚少.
- 实验模型表明,毒素菌可以改变精子和生殖器官的功能.
研究的目的:
- 调查不育男性中抗毒菌抗体的流行情况.
- 探索Toxoplasma gondii感染和精子参数之间的关系,包括形态学和运动性.
- 评估男性人口中感染标志物和水平之间的潜在相关性.
主要方法:
- 一项涉及生育研究中心197名男性志愿者的横截面研究.
- 血清和精液样本被收集用于对抗T. gondiiIgG和IgM抗体的ELISA测试.
- 根据世卫组织的指导方针进行精液分析,评估精子形态和运动性.
主要成果:
- 抗T. gondiiIgG抗体的患病率为48%,其中3%的IgM检测呈阳性.
- 在异常精子形态和非进展性精子 (49.1%) 的男性中发现了更高的抗体百分比.
- 在36-40岁的年龄组中观察到IgG抗体水平最高 (p < 0.001).
结论:
- 在不育男性中抗T. gondiiIgG的高频率表明在男性不育症中可能发挥作用.
- 虽然不是主要原因,但寄生虫可能通过促炎物质和细胞因子导致不孕,影响精子功能.
- 需要进一步的研究来阐明Toxoplasma gondii影响男性生殖健康的确切机制.
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