阻塞性睡眠呼吸暂停和肺癌:分子基础和临床翻译前景
Lin Zhang1, Fengling Liu1, Junyao Li1
1Department of Respiratory and Critical Care Medicine, The Second Hospital of Jilin University, Changchun, China.
Frontiers in cell and developmental biology
|March 2, 2026
概括
阻塞性睡眠呼吸暂停 (OSA) 可能通过促进通过炎症和氧化应激的瘤生长恶化肺癌. 本综述探讨了OSA和肺癌之间的复杂关系,旨在改善患者的治疗结果.
科学领域:
- 肺部病理学 肺部病理学
- 在瘤学瘤学.
- 睡眠医学 睡眠医学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是一种常见的睡眠障碍,与不良健康结果有关.
- 新出现的证据表明,OSA和肺癌之间存在复杂的双向关系.
- OSA可能会促进肺癌的进展,而癌症及其治疗可以加剧OSA.
研究的目的:
- 阐明OSA病理生理学与肺癌瘤微环境之间的复杂联系.
- 探索与OSA相关的肺癌发病和进展背后的分子机制.
- 为临床管理提供见解,并改善患有并发性OSA和肺癌的患者的预后.
主要方法:
- 在PubMed和Web of Science数据库中的系统文献搜索.
- 专注于机理学和临床观察性研究,直到2025年9月.
- 分析OSA的病理生理特征及其对肺癌瘤微环境的影响.
主要成果:
- OSA可能通过慢性炎症和氧化应激促进瘤的进展.
- 肺癌和治疗可以使OSA恶化,从而产生复杂的相互作用.
- 涉及到特定的分子通路,包括外体,瘤相关的巨细胞和癌症干细胞.
结论:
- 了解OSA与肺癌的联系对于患者管理至关重要.
- 对分子机制的进一步研究可以指导治疗策略.
- 在肺癌患者中治疗OSA可能会改善治疗敏感性和整体预后.
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