纳米封装Rhodiola rosea提取物到2-hydroxypropyl-β-cyclodextrin:增强了抗菌和抗癌活动
Shaza Khorshed1, Ahmed Maher Abdeldayem1, Wolfgang Fritsche2
1Department of Chemistry, School of Sciences & Engineering, The American University in Cairo New Cairo 11835 Egypt hazzazy@aucegypt.edu.
RSC advances
|March 2, 2026
概括
罗迪奥拉甲醇提取物 (RRME) 被封装在 (2-hydroxypropyl) -β-cyclodextrin (HPβCD) 中,以形成包含综合体 (RRME-ICs). 这些RRME-IC表现出增强的抗菌和抗癌活性,同时保持抗氧化特性.
科学领域:
- 药理学和植物化学
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
背景情况:
- 罗迪奥拉甲醇提取物 (RRME) 具有抗氧化,抗炎和神经保护性质,这些特性归因于植物化学物质,如沙利德化物,罗莎和醇.
- 这些化合物具有管理与压力相关的疾病和神经退行性疾病的潜力.
研究的目的:
- 将RRME封装到 (2-基) - - 贝塔-环极 (HPβCD) 中,以创建包含综合体 (RRME-IC).
- 评估封装对RRME抗菌,抗氧化和抗癌活性的影响.
主要方法:
- 通过Soxhlet提取提取RRME,并使用HPβCD冷干燥进行封装.
- 描述涉及FT-IR,NMR,TGA和颗粒大小分析.
- 使用MIC90评估抗菌活性,通过DPPH测定评估抗氧化活性,以及对黑色素瘤细胞的抗癌潜力.
主要成果:
- RRME-ICs表现为球形形态 (87.36166.5 nm) 具有高封装效率 (78.88%).
- 鉴定证实了RRME在HPβCD中的成功整合,并增强了热稳定性.
- 与RRME相比,RRME-IC显示了与RRME相比显著改善了对大肠杆菌,P. putida和S. aureus的抗菌活性.
- 抗氧化剂活性被保留 (92.6%的清除),而针对黑色素瘤细胞的抗癌潜力显著增强 (IC50 48.14 μg mL-1).
结论:
- HPβCD纳入复合体形成有效地改善了RRME的抗菌和抗癌特性.
- 封装成功地保留了RRME固有的抗氧化活性.
- RRME-ICs代表了增强治疗应用的有希望的配方.
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