抗逆转录病毒治疗在治疗经验丰富的艾滋病毒感染者之间进行切换
Benjamin Chastek1, Uche Mordi2, Mary J Christoph2
1Optum, Eden Prairie, Minnesota.
Journal of health economics and outcomes research
|March 2, 2026
概括
比克特格拉维尔/emtricitabine/tenofovir alafenamide (B/F/TAF) 有助于艾滋病毒感染者更长时间地维持最初的抗逆转录病毒疗法 (ART). 与其他ART选择相比,这种治疗方案显示了更换或添加药物的风险较低.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 抗逆转录病毒疗法 (ART) 对于治疗艾滋病毒,预防并发症和减少传播至关重要.
- 有治疗经验的艾滋病毒感染者 (PWH) 可能因各种因素而改变ART疗程.
- 了解ART切换模式是优化治疗决策的关键.
研究的目的:
- 为了比较不同ART疗程的PWH之间的治疗切换模式.
- 在一个大型的美国索赔数据库中分析ART切换,包括医疗保险优势注册人.
主要方法:
- 美国索赔数据的回顾性分析 (2017年7月至2023年11月).
- 包括治疗经验丰富的PWH在特定的ART治疗方案中,包括比克特格拉维尔/埃姆特里西塔宾/特诺福维尔阿拉芬胺 (B/F/TAF).
- 使用逆概率治疗权重,卡普兰-梅尔分析和考克斯比例危险模型.
主要成果:
- 这项研究包括了14826个PWH.
- 与其他疗法相比,B/F/TAF的PWH的转换或添加ART的风险明显较低 (P < .001).
- 在B/F/TAF上,PWH的比例更高,在12个月后维持了最初的治疗方案.
结论:
- 在经过治疗的PWH中,B/F/TAF显示治疗更换/补充的可能性较低.
- 在总人口和医疗保险优势子集中,这些发现是一致的.
- 这表明B/F/TAF提供了更大的治疗方案稳定性.
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