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在HIV/SARS-CoV-2同时感染患者的肠道微生物群变化和微生物转位

Xuan Yan¹, Xinyu Zhang¹, Lin Wang¹

¹Department of Infectious Diseases and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.

Frontiers in cellular and infection microbiology

|March 2, 2026

概括

人类免疫缺陷病毒 (HIV) 和严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 的联合感染增加了微生物转移. 在肠道中减少的蓝菌细菌可能表明更严重的COVID-19疾病.

科学领域:

微生物学微生物学
免疫学免疫学免疫学
传染性疾病传染性疾病

背景情况:

人类免疫缺陷病毒 (HIV) 和严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 联合感染带来了独特的挑战.
了解肠道微生物组的变化和微生物转移对于管理同时感染的患者至关重要.

研究的目的:

在HIV/SARS-CoV-2共感染个体的肠道微生物组变化的特征.
在这个人群中识别与COVID-19严重程度相关的微生物特征.

主要方法:

队列研究分析了38名艾滋病毒/艾滋病患者 (20名同时感染者,18名对照者) 的血液和便样本.
测量了血清脂聚糖 (LPS),可溶性CD14 (sCD14) 和zonulin,以评估微生物转位.
进行了便元基因组猎枪测序,以分析肠道微生物群.

主要成果:

同时感染的患者显示血LPS和sCD14水平显著升高.
没有观察到全球肠道微生物群失生症,但在共感染和对照组中发现了独特的微生物物种.
布劳蒂亚属的数量减少与严重至危急的COVID-19病例相关.

结论:

艾滋病毒/SARS-CoV-2联合感染与增加的微生物转移和特定的肠道微生物群变化有关.
蓝斑枯竭可能成为HIV感染个体COVID-19严重程度的生物标志物.

关键词:

艾滋病病毒艾滋病病毒艾滋病病毒这就是SARS-CoV-2病毒.同时感染的同时感染.我们的肠道微生物组.转基因组学是指转基因组学.微生物转移的微生物转移

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