在慢性病 (CKD) 中多种类的益生菌补充:来自印度科专家的见解
Pankaj Beniwal1, Manish Singla2, Deba Prasad Kar3
1Nephrology, Sawai Man Singh (SMS) Medical College, Jaipur, IND.
Cureus
|March 2, 2026
概括
益生菌在通过改善肠道健康和减少毒素来治疗慢性病 (CKD) 方面表现有前途. 需要进一步的研究来确定长期益处,特别是在易受伤害的CKD患者中.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 慢性病 (CKD) 涉及尿素毒素积累和全身炎症,通常与肠道失调有关.
- 肠道功能失调会加剧炎症,并使CKD的治疗变得复杂.
- 益生菌具有恢复肠道健康和减轻CKD并发症的潜力.
研究的目的:
- 评估多种益生菌作为CKD的附加疗法的作用.
- 探索益生菌如何影响肠道微生态,炎症和CKD中的尿素毒素.
- 为印度科专家提供关于CKD中益生菌使用的见解.
主要方法:
- 对特定益生菌菌株的研究进行审查 (例如,斯特雷波可克热菌,乳酸菌,Bifidobacterium longum,Bacillus coagulans).
- 对益生菌对肠道屏障完整性,免疫调节和炎症的影响的分析.
- 评估益生菌对尿液中毒素水平 (硫酸核,硫酸p-) 和功能标志物 (BUN,肌素) 的影响.
主要成果:
- 益生菌显示出抗菌作用,促进有益细菌和抑制病原体.
- 补充剂降低了尿素毒素,BUN,尿素和肌素水平.
- 益生菌增强了肠道完整性,并在CKD 3-5阶段缓解了全身炎症.
结论:
- 多种益生菌是一种有前途的补充疗法,用于CKD患者.
- 益生菌可以改善生活质量,延迟疾病的进展,提高生存率.
- 需要进一步的研究来确定长期益处,特别是在免疫受损或移植患者中.
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