对益生菌和益生菌干预措施的回顾性见解:与肠道微生物群概况和营养结果的关联
Xueli He1, Chaoming Chen2, Lan Shen3
1Department of General Medicine, The Third People's Hospital of Honghe State, Gejiu, Yunnan, China.
Frontiers in nutrition
|March 2, 2026
概括
益生菌和益生菌补充剂显著改变了成人肠道微生物群的组成和多样性. 这些变化与改善的代谢标志物有关,包括降低的BMI和胆固醇水平.
科学领域:
- 微生物组研究的研究.
- 营养科学 营养科学
- 代谢健康 代谢健康
背景情况:
- 众所周知,益生菌和益生菌可以调节肠道微生物群.
- 它们对成人的代谢和营养结果的影响需要在实际环境中进一步研究.
研究的目的:
- 研究益生菌/益生菌前期疗法,肠道微生物群概况和成人营养结果之间的关系.
- 为了阐明针对微生物组的代谢健康策略.
主要方法:
- 这是一项回顾性研究,比较了350名成年人在益生菌,益生菌和对照组.
- 便样本的16SrRNA测序用于在基线和干预后分析肠道微生物群.
- 评估阿尔法和β多样性,以及关键种群的相对丰富性.
- ANCOVA和多变量回归模型用于评估人体指数和生物化学结果 (BMI,脂质资料).
主要成果:
- 益生菌和益生菌补充剂显著增加了肠道微生物的α和β多样性.
- 益生菌的使用增加了乳杆菌和Bifidobacterium的丰富性; 益生菌增加了Bifidobacterium和Faecalibacterium prausnitzii.
- 这两种干预措施都与对照组相比,导致BMI和脂质配置文件的显著改善.
结论:
- 益生菌和益生菌补充剂与增强的肠道微生物群和成人改善的代谢健康有关.
- 这些发现表明饮食微生物群调节的潜在好处.
- 追溯设计限制了得出因果关系结论的能力.
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