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Updated: Mar 3, 2026

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Basophil Activation Test for Allergy Diagnosis
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芝麻过敏的演变 随着时间的推移
Ru-Xin Foong1,2,3, George Du Toit1,3, Henry T Bahnson1,4
1Department of Women and Children's Health (Paediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Allergy
|March 2, 2026
概括
芝麻过敏 (SA) 患病率在儿童中增加,大多数新病例发生在三岁后. 较高的芝麻特异性IgE (sIgE) 和Ses i 1-sIgE水平预测SA发展.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 儿科过敏 儿科过敏
- 临床营养学 临床营养学
背景情况:
- 在全球范围内,芝麻过敏 (SA) 的患病率正在上升.
- 了解SA的自然史和不断变化的生物标志物至关重要.
- 关于儿童随着时间的推移对SA的发展和解决的数据有限.
研究的目的:
- 调查儿童芝麻过敏 (SA) 的自然史.
- 为了分析芝麻过敏生物标志物的变化随着时间的推移.
- 为了比较SA儿童和那些敏感但耐受 (SS) 的儿童之间的生物标志物.
主要方法:
- 对从3个月到7-12岁的纯母乳养婴儿进行长度研究.
- 临床特征的评估,皮肤刺伤测试 (SPT),芝麻特异性IgE (sIgE),Sesi1-sIgE和巨细胞激活测试 (MAT).
- 在7-12岁时确定SA状态,在12个月,36个月和7-12岁时进行生物标志物评估.
主要成果:
- 时段性SA的患病率从0.5% (12-36个月) 增加到1.5% (7-12年),其中71.4%的病例在36个月后出现.
- 与SS儿童相比,在7-12岁的SA儿童显示出较大的SPT,较高的芝麻-sIgE,以及从12个月起的Ses i 1-sIgE.
- 从12个月增加到36个月的芝麻-sIgE和Ses i 1-sIgE的增加率预测了新的SA发展.
结论:
- 在婴儿和青春期前的儿童中,芝麻过敏的患病率显著增加.
- 芝麻特异性IgE (sIgE) 和Ses i 1-sIgE是预测SA发展,持久性和解决的有价值的生物标志物.
- 这些发现强调了监测sIgE水平对于早期识别和治疗儿科芝麻过敏的重要性.
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