臭氧污染可能引发年轻人多发性硬化症:PEDIGREE研究
Roberto Bergamaschi1, Ottavia Eleonora Ferraro2, Pisoni Enrico3
1Multiple Sclerosis Research Unit, IRCCS Mondino Foundation, Via Mondino 2, Pavia, Italy.
Journal of neurology
|March 2, 2026
概括
较高的臭氧 (O3) 暴露增加了儿科多发性硬化症 (pedMS) 的风险. 这项研究发现臭氧含量与儿童多发性硬化症发展之间存在显著联系,这表明空气污染在儿童多发性硬化症中起着作用.
科学领域:
- 环境健康 环境健康
- 儿科神经学 儿科神经学
- 流行病学 流行病学
背景情况:
- 空气污染是成年人多发性硬化症 (MS) 的确定的危险因素.
- 空气污染物对儿科多发性硬化症 (pedMS) 的具体影响仍然不太清楚.
- 调查环境触发因素对于了解多发性硬化症病因至关重要.
研究的目的:
- 检查暴露于特定空气污染物和患儿多发性硬化症 (pedMS) 的风险之间的关联.
- 分析空气污染物数据与儿童队列中MS发病时间的关系.
- 为了确定儿童MS的潜在环境贡献者.
主要方法:
- 这项研究使用了意大利的多中心病例控制设计 (PEDIGREE研究).
- 环境和围产期暴露数据是通过PEQ-IT问卷收集的.
- 空气污染水平 (PM2.5,PM10,O3,NO2,SO2,CO) 是从欧洲监测和评估计划数据库中获得的,用于MS发病前的三年.
主要成果:
- 在较高的臭氧 (O3) 暴露和增加的 pedMS 风险之间发现了统计学上显著的关联.
- 这种关联在MS发病前的第一年,第二年和第三年持续存在.
- 每个单位增加的O3暴露与大约10%的pedMS风险上升相关,即使经过对混因子进行调整.
结论:
- 臭氧 (O3) 暴露成为可能导致儿童多发性硬化症发展的重要因素.
- 这些发现表明,臭氧可能通过涉及炎症和氧化应激的机制促进MS的发展.
- 对空气污染在儿童多发性硬化症中的作用进行进一步研究是有必要的.
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