在双相情感障碍的认知衰退和疾病进展
Isabella S Ji1,2, Kayla M Teopiz1,3, William Cheung1
1Brain and Cognition Discovery Foundation, 77 Bloor Street West, Suite 617, Toronto, ON, M5S 1M2, Canada.
Advances in therapy
|March 2, 2026
概括
双相情绪障碍 (BD) 与认知能力下降有关,一些研究表明执行功能和记忆力较差,情绪发作较多或疾病持续时间较长. 然而,这些发现是混合的,需要更多的研究.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知心理学 认知心理学
背景情况:
- 双极性障碍 (BD) 是一种慢性疾病,其特点是显著的认知缺陷.
- 成年人患有BD时常见的是执行功能,记忆和处理速度受损.
- 认知障碍是BD管理中的一个关键治疗目标.
研究的目的:
- 系统地审查关于疾病进展和认知衰退的临床标志物之间的联系的证据.
- 综合有关疾病持续时间和情绪情节对认知功能的影响的研究结果.
主要方法:
- 在PubMed,OVID (PsycINFO) 和Scopus的系统文献搜索.
- 包括的研究比较了成年人 (≥18岁) 患有BD (I,II或混合) 基于疾病进展标志物.
- 主要结局是通过验证的神经心理测试评估认知功能;各种研究设计有资格.
主要成果:
- 截面研究表明,更多的情绪发作或更长的疾病持续时间与BD中的执行功能和记忆力较差相关.
- 相反,纵向研究发现,与对照人群相比,BD患者随着时间的推移没有显著的认知变化.
- 关于疾病进展标志物和BD认知衰退的证据是不一致的.
结论:
- 双相情感障碍中疾病进展标志物和认知衰退之间的关系是复杂的,并未完全理解.
- 混合的发现突出了对强大的研究设计的需要.
- 未来的研究应该采用大规模的纵向方法,包括生物标志物和神经成像,以阐明BD认知恶化的机制.
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