在工作记忆期间,对动态大脑网络重新配置的遗传控制
Maryam Fatemi1, Mohammad Reza Daliri1
1Neuroscience & Neuroengineering Research Lab., Biomedical Engineering Department, School of Electrical Engineering, Iran University of Science & Technology (IUST), Narmak, Tehran, Iran.
PloS one
|March 2, 2026
概括
遗传因素在工作记忆任务期间影响大脑网络动态. 通过动态连接差量测量的神经灵活性显示出最强的遗传效应,这表明它可能是一种遗传性特征.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 行为遗传学 行为遗传学
背景情况:
- 工作记忆对于认知至关重要.
- 在认知任务期间,动态大脑网络状态的遗传基础尚未得到充分理解.
研究的目的:
- 在工作记忆任务中调查静态和动态功能连接的遗传性.
- 为了确定对认知负载特定神经过程的遗传贡献.
主要方法:
- 检查了单胞胎 (MZ) 和双胞胎 (DZ) 双胞胎执行2背对0背任务.
- 分析了静态和动态的功能连接,包括平均值和差异组件.
- 利用k-means集群来识别反复出现的大脑状态.
主要成果:
- 静态功能连接性显示出中度的遗传性 (约. 0.30),特别是在协会皮层中.
- 动态连接差异表现出最强烈的遗传影响 (约. 0.25-0.44),表明遗传的神经灵活性.
- 无论是国家占用还是切换动态都不是显著的遗传,这表明环境影响.
结论:
- 工作记忆期间对大脑网络的遗传影响遵循梯度:静态连接性是特征类型的,平均动态连接性是任务调制的,动态可变性是高度遗传的.
- 神经灵活性,反映在动态连接性的变化,是一个关键的遗传表型.
- 动态连接性可变性可以作为认知和精神病特征的敏感内分类型.
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