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Updated: Mar 4, 2026

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species
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亨廷顿病LIG1修饰器变体增加了连接酶的忠实性,并抑制了体质CAG重复扩张

Eunhye Lee1,2, Wonju Kim1,2, David H Beier3

  • 1Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114.

Proceedings of the National Academy of Sciences of the United States of America
|March 2, 2026
PubMed
概括

在DNA连接酶1 (LIG1) 中的一种DNA修复基因变体 (K845N) 通过提高DNA修复忠实度和减缓大脑中有害的重复扩张来延迟亨廷顿病的发病.

关键词:
造成的DNA损伤是DNA损伤.基因结合酶1的 DNA 结合酶1亨廷顿病是亨廷顿氏病的一种疾病.维修忠诚度 维修忠诚度 维修忠诚度实体重复扩张的体质重复扩张

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