相关实验视频

Updated: Mar 4, 2026

Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation

Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation

Published on: December 15, 2017

轴极化O-Fe-N₄单原子酶驱动瘤居民细胞内微生物群的清除,并增强免疫疗法

Quan Jing^1,2,3, Jinlong Zhang¹, Zhao He¹

¹CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory of Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China.

|March 2, 2026

概括

这项研究开发了一种基于铁的纳米酶,可以清除内细菌,通过铁亡诱导癌细胞死亡,并通过重塑瘤免疫微环境来增强免疫疗法,以有效治疗癌症.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
免疫治疗是一种免疫疗法.

背景情况:

感冒瘤具有较低的免疫性和免疫逃逸,阻碍了有效的免疫治疗.
内微生物群可以恶化局部免疫抑制,进一步复杂化癌症治疗.

研究的目的:

开发一种高效的基于铁的单原子纳米酶 (Fe SAzyme) 用于癌症免疫治疗.
研究FeSAzyme在降低催化反应的能量障碍和增强免疫反应中的机制.

主要方法:

在石墨烯基底上合成了FeNC SA酶,其轴向O-Fe-N4极化中心.
利用密度函数理论 (DFT) 来验证反应路径和分析电子结构.
开发了一种瘤选择性复合物 (SNAPiFe@RGD),通过超声波激活,产生活性氧物种 (ROS) 和氧化 (NO).

主要成果:

Fe SA 酶对 NADPH 氧化酶,过氧化酶和谷氨氧化酶类反应表现出增强的催化活性.
超声波激活的SNAPiFe@RGD诱导了脂质过氧化和铁,清除了内微生物群,并重塑了免疫微环境.
结合疗法促进了树突细胞成熟和T细胞透,与αPD-L1协同作用以抑制瘤生长.

结论:

开发的FeNC SAzyme平台为癌症免疫治疗提供了一个多机制的策略.
这种方法整合了微生物群清除,氧化还原级联催化,铁灭诱导和免疫检查点阻塞.
该平台可以实现精确且可空间时间控制的癌症免疫疗法.

关键词:

铁素SA酶的使用方法轴向O-Fe-N4 的轴向自由基的产生是自由基的产生.免疫重编程的重编程内微生物群的清除率

更多相关视频

3D Flipwell Engineering for Developing Asynchronous Systems for Toxicologic and Immunomodulatory Therapies in Bacterial, Gut, and Immune Cells

3D Flipwell Engineering for Developing Asynchronous Systems for Toxicologic and Immunomodulatory Therapies in Bacterial, Gut, and Immune Cells

Published on: October 17, 2025

Establishment of a Co-culture System of Patient-Derived Colorectal Tumor Organoids and Tumor-Infiltrating Lymphocytes (TILs)

Establishment of a Co-culture System of Patient-Derived Colorectal Tumor Organoids and Tumor-Infiltrating Lymphocytes (TILs)

Published on: June 27, 2025

相关概念视频

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...