单剂量坦苏洛辛诱导可逆性亚子精和射精功能障碍,这表明可能需要按需的男性避孕药
Leonardo Seligra Lopes1, Julia Domingues Candelaria1, Felipe Placco Araujo Glina1
1Disciplina de Urologia do Centro Universitário FMABC, Santo André, SP, Brasil.
概括
单次0.8毫克的tamsulosin剂量会破坏精液的排放,在大多数男性中导致暂时的精. 这种效应在48小时内是可逆的,这表明男性避孕的可能性.
科学领域:
- 药理学 药理学是指药理学的学科.
- 生殖医学 生殖医学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 射精功能障碍是α-1上腺激素对手的常见副作用.
- 坦素是一种α-1抗剂,经常与性副作用有关.
- 虽然经常被错误地归因于逆行性射精,但tamsulosin的主要作用是在精液排放上,可能导致短暂的精子.
研究的目的:
- 在健康男性中,评估一次0.8毫克的tamsulosin剂量后射精和精液变化的频率,时间和可逆性.
- 为了区分由坦苏洛辛引起的射精变化的机制与逆行性射精.
主要方法:
- 31名健康的男性 (18-45岁) 提供了基线精液分析.
- 精液分析在剂量后24小时间隔六次重复,以描述时间变化.
- 排尿后进行了尿液分析,以检测逆行性射精;统计分析包括重复测量ANOVA和科恩的d.
主要成果:
- 观察到精液体积 (93.6%) 和精子度 (80.7%) 显著下降,剂后12小时达到峰值.
- 在80.7%的参与者中发生过渡性精,在48小时内完全康复.
- 没有检测到逆行性射精的情况;不良反应是轻微的和自我限制的.
结论:
- 一次0.8毫克的tamsulosin剂量暂时抑制精液排放,导致可逆性精在12-48小时内.
- 这些发现支持希望怀孕的男性谨慎使用,并表明tamsulosin可能成为男性按需避孕药.
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