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相关概念视频

Inhaled Medications01:23

Inhaled Medications

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Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
916
Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence01:22

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

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Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
234
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

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Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
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Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
896
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Drug Products: Biologics, Biosimilars and Interchangeables01:28

Drug Products: Biologics, Biosimilars and Interchangeables

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Biologics, derived from living sources such as humans, animals, or microorganisms, represent a significant category of pharmaceuticals. These complex molecules, developed through advanced biotechnological methods or purified from natural sources, include essential medical treatments like insulin and growth hormones. The complexity of biologics arises from their large molecular structures and the intricate processes required for their production, making them distinct from conventional...
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相关实验视频

Updated: Mar 4, 2026

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
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Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

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2024年品牌ICS-LABA吸入器的清单价格下降与通用药物摄入量增加有关.

Jihye Han1, Shirley V Wang2, Aaron S Kesselheim3

  • 1Jihye Han, Vanderbilt University Medical Center, Nashville, Tennessee.

Health affairs (Project Hope)
|March 2, 2026
PubMed
概括
此摘要是机器生成的。

对药品定价的新处罚导致吸入性皮质类固醇长效β-agonist (ICS-LABA) 吸入器的清单价格下降. 通用ICS-LABA的使用显著增加,改善了患者和付款人的负担能力.

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Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models
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Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models

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Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals

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相关实验视频

Last Updated: Mar 4, 2026

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
07:28

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

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Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models
07:56

Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models

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科学领域:

  • 药物经济学 药物经济学
  • 卫生政策 卫生政策
  • 呼吸系统医学 呼吸系统医学

背景情况:

  • 吸入性皮质类固醇长效β-agonist (ICS-LABA) 吸入器是喘和COPD的标准治疗方法.
  • 尽管自2017年以来通用药物可用,但品牌ICS-LABA的使用在美国仍然很高.
  • 2021年"美国救援计划法案"对医疗补助计划的先前清单价格上进行了处罚.

研究的目的:

  • 评估ICS-LABA品牌名单价格降低对仿制药普及的影响.
  • 在政策驱动的价格调整之后,评估通用ICS-LABA利用率的变化.

主要方法:

  • 使用中断时间序列分析.
  • 分析了从2024年1月起的美国全国处方药发行数据.
  • 该研究检查了清单价格下调之前和之后的处方趋势.

主要成果:

  • 从2024年1月开始,通用ICS-LABA的使用量增加了23个百分点.
  • 这一增长主要是由商业计划 (+33个百分点) 和医疗保险 (+24个百分点) 推动的.
  • 清单价格下调可能降低了品牌制造商提供大幅折扣的能力,减少了品牌偏好.

结论:

  • 对ICS-LABAs的政策诱导的清单价格降低可以有效地促进通用竞争.
  • 这些变化提高了患者和医疗保健支付人的基本呼吸道药物的负担能力.
  • 调查结果强调了定价策略和政策干预对药物可获得性的影响.