甲状腺功能障碍症驱动牙周炎的进展通过甲状腺激素诱导的内质网膜应激应激
Huiyi Wang1, Jing Wu1, Zhendong Huang1
1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, China.
Biochemical and biophysical research communications
|March 2, 2026
概括
原发性副甲状腺炎 (pHPT) 会增加牙周炎的风险. 牙周炎可能是pHPT的信号,而内质网膜应激通路为管理与甲状腺功能增强相关的牙周病提供治疗点.
科学领域:
- 内分泌学 在内分泌学.
- 牙周病学 牙周病学
- 遗传学 是一个遗传学.
背景情况:
- 牙周炎很普遍,并且一次性副甲状腺功能障碍症 (pHPT) 可能会使其恶化.
- 对于pHPT和牙周炎之间的因果关系尚不清楚.
- 管理pHPT对于晚期牙周炎 (III/IV阶段) 至关重要.
研究的目的:
- 调查甲状腺功能障碍症对牙周炎的因果关系.
- 探索关联甲状腺功能障碍和牙周炎的潜在机制.
主要方法:
- 一个采用GWAS数据的双样本孟德尔随机化研究.
- 仪器变量包括单核酸多态 (SNP).
- 评估了牙组织和液体中的副甲状腺激素 (PTH) 水平,并分析了内质网膜压力标志物,转录组学和代谢学.
主要成果:
- 甲状腺功能障碍症显著增加牙周炎的风险;没有发现反向因果关系.
- 在牙组织和沟液中观察到PTH水平升高.
- 多omics分析确定了丰富的信号传递和PTH通路,与内质网膜应激减轻PTH诱导的炎症.
结论:
- 牙周炎可能表明潜在的pHPT,建议在牙周炎患者中查甲状腺功能障碍症.
- 细胞内膜网膜应激路径分子是与甲状腺功能障碍相关的牙周病的潜在治疗点.
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