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Updated: Jul 30, 2026

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流速比作为 doxorubicin-loaded 脂质体的微流体合成的一个关键参数

T Hyden-Shepherd¹, M Tiboni², L Casettari²

¹School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.

International journal of pharmaceutics

|March 2, 2026

概括

微流体装置通过调整流速比 (FRR) 来精确控制脂质体药物负载. 这种方法优化了封装效率和颗粒度,用于可扩展的多克索鲁比辛化 (DOX·HCl) 脂质体生产.

科学领域:

生物技术是生物技术.
材料科学材料科学材料科学
制药科学制药科学

背景情况:

微流体装置是脂肪体药物递送系统的可扩展平台.
流速比率 (FRR),药物与脂质 (D/L) 的比率和囊化效率 (EE%) 在脂质体生产中的相互作用尚未完全理解.

研究的目的:

研究FRR和D/L比如何影响脂质体的体性质.
为了优化多克索鲁比辛化 (DOX·HCl) 的被动加载到脂质体中,使用微流体.

主要方法:

使用3D打印的T结微流体芯片用于脂质体生成.
在固定的总流速 (12毫升/分钟) 制造出双 (DOPC) 和 (DOPC:DOPA) 脂质体.
多种FRR (有机:水的比率从3:20到1:3) 和D/L比率,以评估它们对脂质体特征和DOX·HCl封装的影响.

主要成果:

增加FRR降低了脂质体大小 (∼120nm至∼100nm),并增加了颗粒度 (>20倍).
随着D/L比率的下降,DOX·HCl的封装效率 (EE%) 增加,在FRR 1:3的离子脂质体中达到75.5%,达到75.5%.
与脂质度调整相比,通过FRR调节调整D/L比率,显著提高了脂质体度,改善了尺寸/形态的一致性.

结论:

在微流体设备中调节FRR可以精确控制脂质体大小,产量和药物加载效率.
低成本的3D打印微流体系统显示出高吞吐量生产药物装载脂质体的潜力.
在药物输送应用中,FRR是优化脂质体配方和封装的关键参数.

关键词:

德克索鲁比辛是一种多克索鲁比辛.封装封装是一种封装.流量流量流量流量流量脂质细胞体中的脂肪体.微流体学微流体学

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