视觉P300和精神病发病的风险在临床高风险的年轻人
Holly K Hamilton1, Brian J Roach2, Spero Nicholas2
1Department of Psychiatry & Behavioral Sciences, University of Minnesota, Minneapolis, MN; Minneapolis VA Health Care System, Minneapolis, MN; Department of Psychiatry & Behavioral Sciences, University of California, San Francisco, CA.
Biological psychiatry
|March 2, 2026
概括
视觉P300事件相关潜力 (ERP) 缺陷与风险人群中精神病发作有关. 降低P3b振幅预测更早的转化,显示为精神病发展的生物标志物的潜力.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 生物标志物 生物标志物
背景情况:
- 对于预测精神病发作的临床标准是不够的.
- 生物标志物是必要的,以改善临床高危精神病 (CHR) 个体的结果预测.
- 视觉P300事件相关潜力 (ERP) 幅度,已知在精神分裂症下降,在CHR个体中进行了研究.
研究的目的:
- 在CHR个体中检查视觉P300 ERP振幅.
- 为了确定P300振幅是否与未来的精神病发作有关.
- 为了确定精神病发展的潜在生物标志物.
主要方法:
- 脑电图 (EEG) 记录了538名CHR个体和230名健康比较 (HC) 参与者使用视觉奇怪任务.
- 测量了P3b (目标刺激) 和P3a (新刺激) 的幅度.
- 对CHR参与者进行了24个月的跟踪,以比较转换器 (n=71) 和非转换器 (n=218).
主要成果:
- 与HC相比,CHR个体的P300幅度减少了.
- 未来的CHR转换器显示出比非转换器和HC更大的P3b缺陷.
- 降低目标P3b振幅预测了更早的精神病转化,即使在根据症状严重程度进行调整后也是如此.
结论:
- 视觉目标P3b缺陷与风险人群中精神病转化有关.
- 这些缺陷与迫在眉的精神病转化相关.
- 视觉P3b振幅显示为预测精神病发作的生物标志物具有前途.
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