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在排卵触发前几天血清雌激醇水平下降和辅助生殖技术结果之间的关联
Peter Lindner1, Kerry Flannagan2, Charlene Echague1
1Walter Reed National Military Medical Center, Bethesda, MD, USA; Shady Grove Infertility Rockville, US Fertility, Rockville, MD, USA.
Fertility and sterility
|March 2, 2026
概括
在GnRH抗体循环中,在排卵触发前血清雌激醇的下降不会影响可用的母细胞细胞数量或活产率. 卵细胞质量保持可比,无论卵巢刺激期间雌激素的波动.
科学领域:
- 生殖内分泌学和不孕不育问题
- 辅助生殖技术是一种辅助生殖技术.
- 卵巢刺激方案 卵巢刺激方案
背景情况:
- 血清雌激醇水平是受控卵巢刺激期间的关键标志物.
- 在GnRH对抗剂周期中,在排卵触发前雌激醇上升的模式尚未完全理解.
- 雌醇下降对卵细胞质量和周期结果的潜在影响需要研究.
研究的目的:
- 为了评估血清雌激醇下降和GnRH抗剂卵巢刺激周期结果之间的关联.
- 为了确定雌激醇水平的下降是否会影响可用的胚胎细胞的数量和活产率.
主要方法:
- 追溯队列研究,包括使用GnRH抗剂协议 (2010-2021) 的6945个自主检索周期.
- 患者根据排卵触发前四天的血清雌激醇模式进行分类:持续上升,一滴或2-4滴.
- 主要结局:可使用的胚胎细胞的数量;次要结局:卵细胞成熟度,受精,怀孕和活产率.
主要成果:
- 恒定的雌醇升高与一个或多个降低的组之间,可用芽细胞的平均数量没有显著差异.
- 对AMH和女性年龄进行调整后的分析显示了可比的结果.
- 活产率在各组中相似:41.1% (持续上升),36.8% (一次下降) 和42.1% (2-4次下降).
结论:
- 在排卵触发前四天的血清雌激醇下降不会影响GnRH抗剂周期中的卵细胞质量.
- 经历雌二醇波动的患者的生殖结果与恒定的雌二醇升高患者相似.
- 研究结果表明,轻微的雌激素下降不会损害试管婴儿周期的成功.
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