一种热敏喷雾式无接触传递系统,用于烧伤和糖尿病伤口护理
Divyashree Prabhu1, Padmini Ravikumar1, Munira Momin1
1SVKM's, Dr. Bhanuben Nanavati College of Pharmacy, Gate no. 1, Mithibai Campus, Vile Parle (W), Mumbai, 400 056, India.
International journal of biological macromolecules
|March 2, 2026
概括
一种新的热敏凝喷雾剂结合了亚洲酸和黄素,改善了伤口愈合. 这种非接触式输送系统促进了更快的组织再生,并在临床前研究中优于传统治疗方法.
科学领域:
- 生物材料科学 生物材料科学
- 伤口治愈研究研究 伤口治愈研究
- 药物输送系统 药物输送系统
背景情况:
- 对于烧伤和糖尿病伤口而言,无接触药物输送是一个重大挑战.
- 亚洲酸和黄素具有互补的伤口愈合特性:抗炎,抗菌,原合成和组织再生.
- 需要基于聚合物的智能系统来有效的无接触伤口治疗.
研究的目的:
- 开发和优化一个热敏凝喷雾 (TSGS) 无接触输送亚洲酸和黄素.
- 评估亚洲酸和黄素对纤维细胞迁移的体外协同作用.
- 评估优化TSGS配方在促进伤口愈合方面的体内疗效.
主要方法:
- 使用L929小鼠纤维细胞进行了体外理试验,以评估协同效应.
- 使用不同度的基甲基纤维素 (HPMC K100M) 和Poloxamer 407.7制备了9种TSGS配方.
- 在体外释放药物的研究中,评估了凝温度和干燥时间.
- 在生体内对老鼠进行了研究,以比较优化喷雾剂与银硫法酸奶油和常规凝的疗效.
主要成果:
- 试管体内划伤试验显示,活性剂的组合增强了纤维细胞迁移和更快的伤口关闭.
- 与传统凝相比,优化的TSGS在体外释放的两种活性物质显著更高.
- 在老鼠体内研究表明,优化的喷雾显著促进了再上皮化和新血管化.
- 组织病理学证实了优化喷雾所观察到的优质伤口愈合.
结论:
- 开发的热敏凝喷雾剂可有效无接触地提供亚洲酸和黄素.
- 亚洲酸和黄素的组合在伤口愈合上表现出协同作用.
- 优化的TSGS配方显示出治疗烧伤和糖尿病伤口的巨大潜力,性能优于现有的治疗方法.
相关概念视频
01:22Burn Injuries
Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
01:22Drug Delivery: Miscellaneous Routes
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...
01:23Modified-Release Drug Delivery Systems: Classification
Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
01:30Modified-Release Drug Delivery Systems: Stimuli-Activated
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
01:28Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices
Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
01:18Transdermal Drug Delivery Systems
Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...