将地方区域疗法整合到瘤学价值框架中,以改善以患者为中心的决策和结果
Kwabena B Asare1, Benjamin W Corn2, Ronald D Ennis3
1ClearView Healthcare Partners, Boston, MA.
Practical radiation oncology
|March 2, 2026
概括
价值框架 (VFs) 可能会因为不同的终点而低估地方区域疗法. 本审查审查了局部治疗的VF局限性,并提出解决方案,以比较跨模式的价值.
科学领域:
- 在瘤学瘤学.
- 卫生经济学 卫生经济学
- 临床决策 - 临床决策
背景情况:
- 价值框架 (VFs) 对瘤学决策至关重要,评估益处,毒性和成本.
- 目前的虚拟疗法主要评估全身疗法,可能会忽视局部治疗的独特终点.
- 地方区域疗法提供了不同的好处,如器官保存和局部瘤控制,不总是被药物专注的VF捕获.
研究的目的:
- 分析现有价值框架 (VFs) 的局限性,当它们应用于地方区域的癌症疗法时.
- 将当代的虚拟财富分类 (定量,质量,混合) 并评估它们对于评估本地干预措施的适用性.
- 探索在不同治疗方式中比较价值的挑战,并讨论新出现的发展.
主要方法:
- 对瘤学当前价值框架的系统审查和分类.
- 分析系统性和局部区域性癌症治疗之间的终点差异.
- 讨论跨模式价值评估中的挑战.
主要成果:
- 价值框架往往无法充分纳入关键的局部区域终点,如器官功能和局部控制.
- 与全身疗法相比,现有的虚拟疗法可能会系统地低估地方区域干预措施.
- 在比较不同治疗方式的价值方面存在重大挑战.
结论:
- 目前的价值框架需要调整,以准确评估地方区域癌症治疗的价值.
- 开发标准化的方法来比较系统和局部治疗的价值是必不可少的.
- 需要对混合虚拟机和新型指标进行进一步的研究,以确保对所有癌症干预措施的公平评估.
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