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在负的初始标准评估后对β-乳酸盐的重新敏感化:系统性审查和元分析

Witchaya Srisuwatchari¹, Prapasri Kulalert², Thanachit Krikeerati³

¹Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

The journal of allergy and clinical immunology. In practice

|March 2, 2026

概括

在阴性测试后,β-乳酸过敏再敏感化风险很低 (1-4%),严重反应很少发生. 不支持例行重新测试,因为风险反映了一般人群中新的β-乳反应的风险.

科学领域:

过敏和免疫学过敏和免疫学
药理学药理学是指药理学的学科.
临床医学临床医学

背景情况:

贝塔乳 (BL) 过敏诊断和重新测试策略缺乏标准化.
方法的异质性使得对BL的风险评估变得复杂,在负测试后重新敏感化BL.
这导致了关于重新测试BL过敏患者的建议的持续辩论.

研究的目的:

系统地审查和元分析BL复敏的流行率和严重程度.
为了确定BL复敏感化的决定因素.
为了告知安全和个性化的再测试策略对β-乳酸过敏.

主要方法:

在PubMed,EMBASE,Scopus和CINAHL搜索到2024年8月.
包括记录BL过敏和负初始标准评估 (NISE) 患者的研究.
采用随机效应模型进行聚合流行率和子组分析;使用GRADE评估证据强度.

主要成果:

分析了32项有5,766次重复检测的研究;整体聚合复敏率为3.80%.
使用顺序或直接药物诱导测试 (DPT) 的研究显示,复敏率为2.44% (每41次复试1次).
在DPT重复测试期间,严重反应发生在0.32%的患者中;关于患病率的证据强度很低.

结论:

经过负面的β-乳酸过敏评估后,聚合的复敏感化风险很低,特别是与DPT (1-4%).
重复测试期间发生的严重不良事件是罕见的.
调查结果表明,不需要进行常规再检测,因为风险与一般人群中新发反应的风险相当.

关键词:

药物不良反应药物不良反应过敏反应是一种无线性反应.对于β-乳酸过敏的反应延迟标记是什么意思药物过敏药物过敏药物过敏进行元分析分析.青素过敏青素过敏皮肤测试皮肤测试系统性审查系统性审查

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