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[肝癌转化疗法的术后安全性分析:单中心回顾性研究]

Z W Wei¹, J Q Cai¹

¹Department of Hepatobiliary Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Zhonghua wai ke za zhi [Chinese journal of surgery]

|March 2, 2026

概括

术后的转化疗法是最初无法切除的肝细胞癌 (HCC) 的可管理方法. 这种治疗提供了手术机会,并促进了HCC患者的长期存活.

科学领域:

肝胆道手术肝胆道手术
在瘤学瘤学.
胃肠病学胃肠病学

背景情况:

肝细胞癌 (HCC) 带来了挑战,特别是当最初无法切除时.
转换疗法之后的手术切除是高级HCC的新兴策略.
评估这种连续方法的术后安全性和结果至关重要.

研究的目的:

调查HCC转换疗法的术后安全性.
评估转换疗法后连续手术切除的疗效和结果.
分析最初无法切除的HCC患者的生存率和并发症.

主要方法:

45名最初无法切除的HCC患者的回顾性病例系列.
收集了关于临床特征,转化疗法和手术结果的数据.
使用Kaplan-Meier和Log-rank测试进行生存分析.

主要成果:

转化疗法后的目标响应率为48.9%,疾病控制率为100%.
病理完整反应 (pCR) 率为20.0%,主要病理反应 (MPR) 率为26.7%.
可管理的不良反应 (84.4%) 和术后并发症 (55.6%),1年和3年的生存率分别为93.33%和80.42%.

结论:

术后的转化疗法是最初无法切除的HCC的安全有效策略.
这种方法提供了手术选择,并改善了长期生存前景.
副作用和并发症是可以管理的,支持其临床实用性.

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