撒哈拉以南非洲地区的急性输血反应:系统审查和元分析
Stephen Twumasi1, Lilian Antwi Boateng1,2, Alain Mayindu Ngoma3
1Department of Medical Diagnostics, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Vox sanguinis
|March 2, 2026
概括
在撒哈拉以南非洲,急性输血反应 (ATR) 很常见,特别是在全血输血时. 实施血液成分治疗和改善血液警可以显著减少这些不良事件.
科学领域:
- 血液学 血液学 血液学
- 公共卫生 公共卫生
- 临床医学 临床医学
背景情况:
- 撒哈拉以南非洲 (SSA) 面临着血液监测方面的挑战,在输血后增加不良事件的风险.
- 急性输血反应 (ATR) 在该地区对患者安全构成重大威胁.
研究的目的:
- 系统地审查和元分析SSA中ATR的频率,临床模式和决定因素.
- 在撒哈拉以南非洲为ATR预防提供基于证据的策略.
主要方法:
- 按照PRISMA指南进行系统审查和元分析.
- 研究按设计分层 (回顾性和前性).
- 使用随机效应元分析计算的聚合比例.
主要成果:
- 包括来自13个SSA国家的26项研究.
- 每个患者的ATR比率:64/1000 (追溯) 和112/1000 (前).
- 每个单位的ATR汇总率:23/1000 (追溯) 和136/1000 (前).
- 最常见的反应:发烧性非血液溶解性 (41.8%) 和过敏性 (24.9%).
- 危及生命的反应发生在14%的患者中;0.94%的患者死亡.
- 与ATRs相关的因素:全血输血,多个单位和以前的输血暴露.
结论:
- 在SSA中,ATRs很常见,与全血使用密切相关.
- 血液成分治疗可以大大降低ATRs的负担.
- 关键的预防策略包括加强输血前评估,扩大白血病减少,建立强有力的血液警,并促进适当的血液使用.
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