抑郁症可能不是心血管疾病患者死亡的独立风险因素:来自NHANES 2011-2018年的数据
Bao The Nguyen1,2, Yi-Chang Li2, Hoang Nhat Dang3
1Hue University of Medicine and Pharmacy, Hue, Viet Nam.
Open heart
|March 2, 2026
概括
抑郁症不是心血管疾病 (CVD) 患者死亡的独立风险因素. 对混因素进行严格的控制分析发现,抑郁症状与该人群死亡风险增加之间没有明显的关联.
科学领域:
- 心脏病学 心脏病学
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 心血管疾病 (CVD) 是全球主要的死亡原因.
- 抑郁症在心血管疾病患者中很常见,以前被认为是独立的死亡风险因素.
- 最近的研究表明,混因素可能会影响心血管疾病中抑郁症与死亡率的联系.
研究的目的:
- 调查临床显著的抑郁症状与心血管疾病成年人的死亡风险之间的关联.
- 在与抑郁症有关的所有原因,心血管和非心血管死亡率之间进行区分.
- 评估抑郁症是否在考虑混变量后仍然是一个独立的风险因素.
主要方法:
- 从国家健康和营养检查调查 (2011-2018) 中对2064名患有心血管疾病史的成年人进行二次分析.
- 使用患者健康问卷-9 (PHQ-9) 评估抑郁症,值为≥10.
- 多变量考克斯回归,倾向得分匹配和反向概率权重用于控制混.
主要成果:
- 超过4.67年的中位数随访,发生了403例死亡.
- 最初的分析显示,抑郁症与较高的全因和非心血管死亡率有关 (HR分别为1.33和1.46).
- 在倾向分数匹配和逆概率加权后,这些关联在统计学上并不显著.
结论:
- 抑郁症不是心血管疾病患者死亡的独立预测因素.
- 严格对混因子和并发症进行调整,可以否定之前观察到的关联.
- 调查结果强调了在心脏病和抑郁症研究中考虑混因素的重要性.
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