光学连贯断层扫描血管造影揭示了微血管变化,并预测了下垂体腺瘤减压手术后的视觉结果
Ivan Pochou Lai1, Ching-Wen Huang1,2, Shih-Hung Yang3
1Department of Ophthalmology, National Taiwan University Hospital, Taipei City, Taiwan.
The British journal of ophthalmology
|March 2, 2026
概括
光学连贯断层扫描血管学 (OCTA) 揭示了下垂体腺瘤手术后视网膜微血管变化. 视网膜血管密度和神经纤维层厚度可以预测患者的视觉结果和恢复.
科学领域:
- 眼科医生 眼科 眼科
- 神经科学是一个神经科学.
- 医疗成像医学成像
背景情况:
- 垂体腺瘤可能会导致视野缺陷,由于视神经的压缩.
- 转形手术是对垂体腺瘤的常见治疗方法.
- 评估手术后视觉恢复对于患者管理至关重要.
研究的目的:
- 用OCTA评估视网膜微血管变化,用于为垂体腺瘤进行跨形手术的患者.
- 为了确定这些微血管变化对视觉恢复的预后价值.
主要方法:
- 对90名接受过脑膜外科手术的患者进行前性研究.
- 评估最佳校正的视力敏度 (BCVA),视野平均偏差 (MD) 和OCTA参数 (黄斑和周围毛囊).
- 与视敏度和视野结果相关联的OCTA发现.
主要成果:
- 严重的视野缺陷与减少的表面毛细管 (SCP) 和辐射周毛细管 (RPC) 密度相关.
- 较高的SCP密度,RPC密度,周状视网膜神经纤维层 (pRNFL) 厚度和状细胞复合体 (GCC) 厚度与更好的视觉敏度和MD相关.
- 在轻度至中度视野缺陷中,状参数预测了视觉敏度,而在严重病例中,SCP,RPC,pRNFL和GCC是预后.
结论:
- 视网膜血管密度可能会在手术后下降,特别是在严重的基线视野缺陷中.
- 像SCP密度,RPC密度,pRNFL厚度和GCC厚度这样的OCTA参数是预测垂体腺瘤手术后视觉恢复的有价值的生物标志物.
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