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关于心脏移植接受者非传染性炎症性肠病的流行率,风险因素和结果的单一中心调查

Emanuele Durante-Mangoni¹, Oriana Infante¹, Sabiha Gul¹

¹University of Campania "L. Vanvitelli" and AORN Ospedali dei Colli-Monaldi Hospital, P. Ettore Ruggieri, Naples, Italy.

Transplantation proceedings

|March 2, 2026

概括

在心脏移植 (HTx) 后,可能会出现新的炎症性肠病 (IBD). 细胞巨乳病毒的重新激活和高水平的免疫抑制剂是HTx患者新发IBD的潜在危险因素.

科学领域:

心脏病学心脏病学
胃肠病学胃肠病学
免疫学免疫学免疫学

背景情况:

炎症性肠病 (IBD) 是一种免疫媒介的疾病.
心脏移植 (HTx) 是一种治疗心力衰竭的方法.
在HTx后的免疫抑制可能会影响免疫媒介疾病,包括新的IBD.

研究的目的:

描述HTx后新发IBD的临床特征.
确定影响HTx后新IBD发病的变量.

主要方法:

在一个单一中心进行回顾性,观察性研究.
包括在HTx后被诊断为非传染性IBD的住院患者.

主要成果:

包括10名男性患者;IBD发病时的中位数年龄为56岁.
从HTx到IBD诊断的中位时间为8.5年.
常见的症状包括直肠出血,腹痛和腹;60%的患者先前有细胞大脑病毒的重新激活;观察到高水平的免疫抑制剂.

结论:

在HTx之后,IBD是De novo的潜在并发症.
在HTx患者中怀疑IBD,有持续的胃肠道症状.
细胞巨乳病毒的重新激活和高免疫抑制剂的暴露是潜在的危险因素.

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