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移植后持续性尿路感染:风险因素和管理
Amil Huseynov1, Sevim Nuran Kuşlu Çiçek2
1Beykoz University, İstanbul, Türkiye.
Transplantation proceedings
|March 2, 2026
概括
持续性尿路感染 (UTI) 在移植患者中很常见. 糖尿病,导管使用和多耐药 (MDR) 病原体是这些难以治疗的感染的关键风险因素.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 传染性疾病 传染性疾病
- 移植免疫学 移植免疫学
背景情况:
- 持续性尿路感染 (UTI) 对移植接受者来说是一个重大挑战,增加了发病率,并可能损害了移植功能.
- 有效的管理策略和风险因素的识别对于这个脆弱的人群至关重要.
研究的目的:
- 确定移植患者持续性尿路感染的独立预测因子.
- 分析持续性尿路感染对移植功能和结果的影响.
主要方法:
- 从2020年1月到2024年12月,对1130名移植接受者的回顾性分析.
- 收集的数据包括人口统计,免疫抑制,微生物学和治疗结果.
- 使用多变量逻辑回归来确定持续性尿路感染的独立风险因素.
主要成果:
- 31.2%的受试者患有持续性尿路感染,68.5%的受试者经历了反复发作.
- 显著的危险因素包括糖尿病 (aOR 1.56),延长的尿导管 (aOR 2.04) 和多药性 (MDR) 病原体 (aOR 2.32).
- 大肠杆菌是最常见的病原体;在患有持续性尿路感染的患者中观察到较低的EGFR,但移植损失率相似.
结论:
- 持续性尿路感染是移植患者的一个主要临床问题.
- 可修改的风险因素,如血糖控制和尿导管管理,是减少复发和保持功能的关键目标.
- 常规监测和明智的抗生素使用对于管理MDR生物和改善患者结果至关重要.
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