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工程NIR-II碳点通过烯延伸与石墨烯和丰富,用于肝胆腺透症

Lijuan Yang^1,2, Man Li^1,2, Yisheng Peng¹

¹Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China.

Nature communications

|March 2, 2026

概括

我们开发了可调节近红外II辐射的新型碳点 (CD),用于深层组织成像. 这些CD可以进行增强的胆囊成像,并显示肝纤维化治疗的潜力.

科学领域:

纳米材料科学科学纳米材料科学
生物医学工程生物医学工程
有机化学有机化学

背景情况:

近红外II (NIR-II) 碳点 (CDs) 为生物医学成像提供深层组织透.
在合成NIR-IICD和理解其光发光机制方面存在挑战.

研究的目的:

为了合成具有可调节发射的NIR-IICD.
在CD中阐明NIR-II红移背后的机制.
为了建立一个纳米平台,用于肝胆透视.

主要方法:

从p-phenylenediamine中合成了三种CD (CDs-1,CDs-2,CDs-3) 使用扩展的林基框架.
采用结构和密度函数理论 (DFT) 分析.
评估了用于胆囊成像的CDs-3,并开发了用于肝纤维化疗法的化CDs-3@pPB.

主要成果:

从可见到NIR-II (480-1265nm) 实现了可调节的发射.
NIR-II红移归因于增强的分子二极子时刻,电子受体能力,石墨烯域积累和酸兴奋剂.
在胆囊成像中,CDs-3显示透深度为15毫米,超过了氨酸绿色.
CDs-3@pPB在肝纤维化中显示出强大的反应性氧物种清除和治疗性疗效.

结论:

在CD中阐明了NIR-II发射的机制.
建立了一个纳米平台 (CDs-3@pPB) 用于具有显著临床潜力的肝胆疗术.

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