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Updated: Mar 4, 2026

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在子宫内膜癌中HRD:LST损失驱动着独特的基因组特征和白金反应

Ting Wan1,2, Qiaqia Li1,2, Wen Hao3,4

  • 1Department of Gynecologic Oncology, Sun Yat-sen University Cancer Center, Guangzhou, PR China.

NPJ precision oncology
|March 2, 2026
PubMed
概括

在子宫内膜癌 (EC) 中,同源重组缺陷 (HRD) 主要是由大规模过渡 (LST) 损失驱动的,而不是短核酸变异. 这种HRD表型影响无进展生存和敏感性,作为一个关键的生物标志物.

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