患者报告的细胞还原性手术和高温腹腔内化学疗法的财务毒性
Vladislav Kovalik1, Armando Sardi2, Luis Felipe Falla-Zuniga1
1Mercy Medical Center, Baltimore, MD, USA.
Annals of surgical oncology
|March 2, 2026
概括
财务毒性 (FT) 显著影响细胞还原手术与高温腹腔内化疗 (CRS/HIPEC) 患者的生活质量 (QoL). 治疗后的一年,财务状况有所改善,但化学疗法和共同支付等风险因素仍然存在.
科学领域:
- 在瘤学瘤学.
- 卫生经济学 卫生经济学
- 患者报告的结果
背景情况:
- 细胞还原性手术与高热性腹腔内化疗 (CRS/HIPEC) 是一种复杂的治疗,与潜在的财务毒性 (FT) 相关.
- FT可以对癌症幸存者的生活质量 (QoL) 产生负面影响.
- 了解FT的驱动因素和轨迹对于支持性护理至关重要.
研究的目的:
- 评估通过高温腹腔内化疗 (CRS/HIPEC) 进行细胞减小手术的候选人和幸存者的财务毒性 (FT).
- 调查FT与生活质量 (QoL) 之间的关联.
- 探索 FT 随着时间的推移所产生的动态和贡献因素.
主要方法:
- 这是一项涉及248名参与者 (候选人和幸存者) 的横截面研究,他们接受了CRS/HIPEC.
- 使用了财务毒性综合评分 (COST) 和癌症治疗一般功能评估 (FACT-G) 调查.
- 采用斯皮尔曼相关性和通用线性模型来分析FT,QoL和风险因素.
主要成果:
- 31%的参与者经历了中度至严重的金融毒性 (FT).
- 在FT (COST分数) 和QoL (FACT-G分数) 之间发现了强烈的相关性 (rho = 0.51,p < 0.001).
- 增加FT的风险因素包括术前化疗,识别为有色人种,单身和更高的共同支付;FT在治疗后一年显著下降.
结论:
- 对于CRS/HIPEC患者来说,金融毒性 (FT) 是一个重大问题,与较差的生活质量 (QoL) 密切相关.
- 定期手术化疗,共同支付和社会人口统计学因素是FT的关键驱动因素.
- 患者的财务状况在CRS/HIPEC后的一年内有所改善.
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