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在欧亚黑鸟 (Turdus merula) 中,乌苏图病毒相关疾病的神经病变发生涉及通过外部途径的亡

Giuseppe Giglia^1,2, Gianfilippo Agliani², Bas B Oude Munnink³

¹Department of Veterinary Medicine, University of Perugia, Perugia, 06126, Italy.

Journal of neurovirology

|March 2, 2026

概括

欧亚黑鸟感染的乌苏图病毒 (USUV) 引发了细胞亡,这是细胞死亡的关键途径. 外在的亡途径更活跃,对与USUV相关的大脑损伤作出了重大贡献.

科学领域:

兽医病毒学兽医病毒学
神经科学是一个神经科学.
细胞生物学细胞生物学

背景情况:

乌苏图病毒 (USUV) 是一种引起鸟类系统性和神经侵入性疾病的动物性树状病毒.
鸟类中USUV相关脑炎中细胞损伤的机制尚未完全理解.
亡是已知的贡献者神经病理在相关的病毒.

研究的目的:

对欧亚黑鸟 (Turdus merula) 中的USUV相关脑炎中亡的参与进行调查.
为了比较USUV感染期间外部和内在亡途径的激活.

主要方法:

对黑鸟大脑进行了切割caspase-3 (CC3) 的免疫组织化学检测.
道测试用于检测亡细胞.
用RT-qPCR量化caspase 8 (外部) 和caspase 9 (内在途径) 的mRNA水平.

主要成果:

与未感染的对照组相比,USUV感染的黑鸟显示出明显更高的CC3表达和TUNEL阳性细胞数量.
在USUV感染的鸟类中,酶8和酶9的mRNA水平都被上调.
外在途径 (caspase8) 的上调调节明显高于内在途径 (caspase9).

结论:

亡在欧亚黑鸟的USUV相关脑炎中起着重要作用.
在USUV感染期间,外在和内在的亡途径都被激活.
外在的亡途径在USUV诱导的大脑损伤中更为突出.

关键词:

飞行员飞行员飞行员飞行员细胞死亡 - 细胞死亡外在的亡是外在的亡.神经病理学神经病理学乌苏图病毒是一种病毒.

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