在长期COVID患者中,轻度认知障碍的发生率增加
Jennifer A Frontera1, Arjun V Masurkar1, Rebecca A Betensky2
1New York University Grossman School of Medicine, New York, New York, USA.
概括
与康复的COVID-19患者和对照人群相比,长期COVID患者在4.4年内出现轻度认知障碍 (MCI) 的发生率显著更高. 这种增加的风险包括与阿尔茨海默病相关的MCI.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 认知科学 认知科学
背景情况:
- 脑雾是长期COVID的常见症状之一.
- 在长期COVID患者中,轻度认知障碍 (MCI) 的发生率在很大程度上是未知的.
- 了解COVID-19后的认知缺陷对于患者管理至关重要.
研究的目的:
- 为了确定长期COVID患者中MCI的发生率.
- 为了比较长期COVID,康复COVID-19和COVID阴性个体之间的MCI风险.
- 调查长期COVID和与阿尔茨海默病相关的MCI之间的关联.
主要方法:
- 进行了一项观察性队列研究.
- 研究对象包括康复的COVID-19,长期COVID和COVID负组.
- 盲目的评估使用了国家阿尔茨海默氏症协调中心 (NACC) 和国家老龄研究所 (NIA) 对痴呆和MCI的标准.
主要成果:
- 在长期COVID患者中,4.4年的MCI累积发病率为27%,而在康复COVID-19患者中为5%,在COVID-阴性对照中为1%.
- 长期COVID患者患上MCI的风险明显更高 (HR 3.93).
- 在长期COVID患者中观察到与阿尔茨海默病相关的MCI的风险更高 (HR 3.20).
结论:
- 长期COVID与MCI的累积发病率和危险性显著增加有关.
- 风险扩展到特定的亚型,包括与阿尔茨海默病相关的MCI.
- 这些发现强调了COVID-19感染的长期神经影响.
关键词:
阿尔茨海默氏症的疾病是阿尔茨海默氏症.根据COVID-19的情况,在MCI中,MCI是MCI.在SARS-CoV-2中.认知 认知 认知累积发生率是累积发生率.痴呆症 痴呆症是一种痴呆症.发生率的发生率.长期COVID的情况长途运输车的长途运输车.轻度的认知障碍 轻度的认知障碍后COVID综合征是什么意思在COVID的后急性后果.更多相关视频
06:23The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease
Published on: October 13, 2016
34.0K
07:42Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients
Published on: December 16, 2022
3.8K
相关概念视频
Cognitive Development During Adulthood
1.0K
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
1.0K
COPD: Pathogenesis and Clinical Features
2.0K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
2.0K
Long-term Depression
3.5K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
Calcium Ion Concentration Mechanism
If over...
3.5K
Long-term Depression
33.5K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.5K
Alzheimer's Disease: Overview
1.9K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.9K
Negative and Cognitive Symptoms of Schizophrenia
792
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
792
