在膝关节骨关节炎患者中,联合运动和食补充剂干预的补充作用:随机,双盲,安慰剂对照试验的研究协议
Tina Čeh1,2, Jernej Završnik3, Nejc Šarabon4,5
1, Community Healthcare Center Dr. Adolf Drolc, Maribor, Slovenia. tina.ceh@zd-mb.si.
Trials
|March 2, 2026
概括
这项研究调查了将运动与葡萄糖胺和原蛋白补充剂相结合是否可以改善膝关节骨关节炎 (KOA) 症状. 这些发现可能为KOA患者的疼痛和功能提供新的非侵入性策略.
科学领域:
- 整形外科和运动医学
- 营养科学 营养科学
- 康复 康复 康复 康复
背景情况:
- 膝关节关节炎 (KOA) 是一种普遍的疾病,引起疼痛,硬和功能减弱,特别是在老年人中.
- 运动和食补充剂是常见的KOA管理策略,但它们的综合效应仍未得到充分研究.
- 这项研究解决了评估运动和补充剂对KOA症状的协同影响的需要.
研究的目的:
- 评估联合监督抗力运动与葡萄糖胺和原蛋白补充剂在治疗KOA中的有效性.
- 为了比较对运动的联合干预与安慰剂和仅补充的干预.
- 评估KOA患者疼痛,身体功能和生活质量的改善.
主要方法:
- 一项涉及55岁以上KOA患者的试验随机分为三个组:仅补充剂,运动与补充剂以及运动与安慰剂.
- 一个为期12周的受监督的力量训练计划与葡萄糖胺和原蛋白补充剂相结合.
- 通过验证的问卷 (WOMAC,SF-36),NRS和身体功能测试 (例如,30s椅子站,40m步行,TUG,Star Ex,6MWT,平衡,MVIC) 来测量结果.
主要成果:
- 主要结局包括在基线,13周和18周评估的疼痛水平和身体功能的变化.
- 二次结果评估将捕捉功能改善和生活质量变化.
- 统计分析将比较综合干预与对照组的影响.
结论:
- 这项研究旨在阐明运动和食补充剂对KOA的综合益处.
- 结果将解决了解补充剂是否增强基于炼的KOA管理的差距.
- 结果可以为临床实践提供信息,促进潜在的非侵入性治疗,以改善KOA患者的治疗结果.
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