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2022年西班牙活跃HCV感染的患病率使用多参数证据合成.

Christos Thomadakis1,2, Ilias Gountas1, Konstantinos Gountas1

  • 1Medical School, University of Cyprus, Nicosia, Cyprus.

Journal of viral hepatitis
|March 3, 2026
PubMed
概括

西班牙西班牙西班牙西班牙西班牙

关键词:
贝叶斯的证据综合学西班牙西班牙西班牙西班牙西班牙有活跃的HCV感染.关键人群是关键的人群.人口流行率的人口流行率.

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科学领域:

  • 肝病学和传染病.
  • 公共卫生和流行病学.
  • 贝叶斯统计模型.贝叶斯统计模型.

背景情况:

  • 型肝炎病毒 (HCV) 感染是全球性的健康问题.
  • 西班牙的直接作用抗病毒 (DAA) 计划旨在减少HCV的流行.
  • 关于西班牙活跃HCV感染 (aHCV) 患病率和趋势的准确数据有限.

研究的目的:

  • 估计2022年西班牙HCV的流行率.
  • 分析2019年至2022年HCV流行率的变化.
  • 识别高风险人群和未被诊断的病例.

主要方法:

  • 使用贝叶斯的多参数证据综合 (MPES).
  • 研究群体 (15-79岁) 被分为风险组:目前注射毒品的人 (PWID),前PWID,同性恋双性恋和其他与男性发生性关系的男性 (GBMSM) 参与化学性行为 (GBMSMchem) 和普通人群.
  • 综合了来自血清流行调查,行为研究,国家数据库和DAA治疗记录的数据.

主要成果:

  • 2022年西班牙的aHCV总体患病率估计为0.14% (约. 54,500个个体) 的情况.
  • 在当前PWID (12.5%) 和GBMSMchem (8.4%) 中,患病率最高.
  • 从2019年到2022年,观察到~2万个aHCV病例的下降,归因于DAA治疗. 在一般人群中,未被诊断的病例为29.4%,在50-69岁的人群中最高.

结论:

  • 西班牙在消除HCV方面取得了进展,通过DAA治疗显著减少了病例.
  • 关键人群,包括PWID和GBMSMchem,仍然面临活跃HCV感染的高风险.
  • 有针对性的干预,减少危害和可访问的测试/治疗对于实现世卫组织2030年消除目标至关重要.