牙科微塑料作为新兴的神经毒剂:对人类数据的系统审查
Aiah Alkhamees1, Dana Salha1, Dana Alfailat1
1College of Dental Medicine, University of Sharjah, Sharjah, United Arab Emirates.
PeerJ
|March 3, 2026
概括
微塑料暴露可能会影响大脑功能,人类研究表明相关性,而体外研究揭示了分子机制. 然而,目前的证据有限,需要进一步的纵向研究来确定因果关系.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 毒理学 毒理学 毒理学
背景情况:
- 微塑料和相关化合物是新兴的环境污染物.
- 潜在的神经效应正在调查中,但研究结果不一致.
- 本综述综合了关于微塑料暴露和神经结果的最新数据.
研究的目的:
- 系统地审查关于微塑料和神经效应的最新数据.
- 从人体和体外研究中收集证据.
- 评估微塑料暴露与大脑功能之间的联系.
主要方法:
- 在PubMed,Scopus,MEDLINE,EBSCO和ScienceDirect中进行了搜索 (2015年1月至2025年12月).
- 包括对微塑料,纳米塑料或与塑料相关的化学物质和神经结果的研究.
- 评估了使用纽卡斯尔-太华尺度的人类研究和使用ToxRTool的体外研究.
主要成果:
- 18项研究符合纳入标准 (9项人类观察,1项死后,8项实验室).
- 人类研究显示了微塑料暴露与改变认知/生物标志物之间的相关性,但缺乏因果关系.
- 在体外研究中发现了氧化应激和线粒体功能障碍等机制.
结论:
- 有证据表明,微塑料可能会对神经系统产生影响,这些证据得到了体外和人体数据的支持.
- 目前的研究主要是观察性的,限制了因果结论.
- 需要进一步的纵向人类研究来确定剂量反应和现实世界的适用性.
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