关于维生素D缺乏对COVID-19和C型肝炎患者血小板指数的影响的比较研究;一个观察性比较研究
Mohammad Motaghi1, Kazem Ghaffari2,3,4, Mahroo Mansori1
1Department of Biochemistry and Hematology Semnan University of Medical Sciences Semnan Iran.
Health science reports
|March 3, 2026
概括
与C型肝炎病毒患者相比,COVID-19患者的维生素D水平较低,血小板参数发生变化. 这些发现表明,维生素D缺乏可能会加剧COVID-19的炎症和血栓形成风险.
科学领域:
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
- 内分泌学 在内分泌学.
背景情况:
- 有限的证据将维生素D与COVID-19和C型肝炎病毒 (HCV) 感染中的血小板参数联系起来.
- 鉴于维生素D在免疫力中的作用以及对血栓性并发症的潜在影响,研究这种关联至关重要.
研究的目的:
- 评估COVID-19和慢性HCV患者的血清维生素D水平和血小板指数之间的关系.
- 为了比较COVID-19和HCV患者之间具有不同维生素D状态的血小板参数和炎症标志物.
主要方法:
- 一项涉及113名COVID-19患者和97名慢性HCV患者的比较研究.
- 参与者被分为维生素D缺乏和不缺乏的子组.
- 统计分析包括千平方或费舍尔精确测试.
主要成果:
- COVID-19患者的维生素D水平明显低于HCV患者 (p < 0.001).
- COVID-19患者的血小板数量较低,MPV,PDW和炎症标志物 (PLR,MPR,MLR) 较高.
- 在两组中都观察到维生素D和MPV之间的负相关性 (p < 0.001),而维生素D缺乏的COVID-19患者的变化更为明显.
结论:
- 与HCV相比,COVID-19与维生素D的降低,血小板数量的减少和血小板激活的增加有关.
- 这些变化可能导致COVID-19中观察到的炎症反应加剧和血栓性并发症.
- 维生素D状况似乎影响了感染性疾病中血小板和炎症变化的严重程度.
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